Pyrexia of Unknown Origin: A High Suspicion of COVID-19

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Ashish Chauhan
Ankit Bisen
Papabathini Shireen Salome


We report a case of pyrexia of unknown origin (PUO) in a 19-year-old male, who was admitted with a history of pyrexia for 2 weeks. The diagnosis remained uncertain despite multiple investigations and the patient subsequently had various clinical manifestations similar to those seen in coronavirus disease 2019 (COVID-19). Since it was initially presumed to be pyrexia due to viral origin or enteric fever, patient was started on empirical treatment. The diagnosis of COVID-19 was confirmed by corroborating various biochemical markers that had a greater association with COVID-19. Patient was discharged after 21 days with empirical antibiotics, anticoagulants and other supportive medications. He required no further hospital admissions and has been on regular follow-up.

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Ashish Chauhan, Ankit Bisen, Sreelakshmi, & Papabathini Shireen Salome. (2022). Pyrexia of Unknown Origin: A High Suspicion of COVID-19. Indian Journal Of Clinical Practice, 33(5), 32–36. Retrieved from
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