Sepsis – An Impendence That Needs a Global Solution Know Safety – No Infection
Keywords:
Staphylococcus aureus bacteria,, septic shock, 25-hydroxyvitamin D, hospital-acquired infection, bloodstream infections, cytokines, anion gapAbstract
Sepsis has been called a hidden public health disaster. Sepsis arises from the host response to infection, which is directed to kill
the invading pathogens. It is an extreme response to an infection and one of the most common causes of multiorgan failure.
The human body sends a flood of chemicals into the bloodstream to fight the threat. This causes widespread inflammation
which, over time, can slow blood flow and damage the organs. Sepsis is clinically diagnosed by a combination of clinical
signs, laboratory tests and microbiologically confirmed by the detection of bacteria in blood by culture. Early and aggressive
management with appropriate antimicrobials and rapid and complete hemodynamic stabilization has been shown to be
associated with improved outcomes. Detecting sepsis early and starting immediate treatment is often the difference between
life and death.
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