Efficacy and Safety of Combination of Noscapine and Chlorpheniramine in Management of Cold and Cough

Abstract

Cough is one of the most common symptoms for which patients visit the doctor. Because of its broad differential diagnosis,
cough is a challenging condition to manage. Antitussives or cough suppressants are indicated if cough interferes with daily
activities. Cough suppressants not only provide symptomatic relief by decreasing cough, they also prevent the spread of
infection. Noscapine is a non-narcotic cough suppressant, which relieves cough by acting at the level of the cough center
in the brain. It does not cause significant sedative, euphoric, or hypnotic effects, and other side effects such as respiratory
suppression and constipation that are typically associated with opioids. Hence, unlike other opioid antitussives such as
codeine, noscapine is nonaddictive.