Effectiveness and Safety of Combination of Milk of Magnesia, Liquid Paraffin, and Sodium Picosulfate Oral Emulsion for Treatment of Chronic Constipation in Patients with Comorbidities
DOI:
https://doi.org/10.59793/v2pbx144Abstract
Chronic constipation in patients with type 2 diabetes mellitus (T2DM), hypothyroidism, and hypertension
significantly impact quality of life. Evidence supporting combination laxative therapy in this population remains limited. This
pilot study evaluated the effectiveness, safety and tolerability of a fixed-dose oral emulsion containing milk of magnesia, liquid
paraffin, and sodium picosulfate. Methods: In this prospective, single-arm, 50 adults with chronic constipation and T2DM,
hypothyroidism, and/or hypertension received the fixed-dose combination of milk of magnesia, liquid paraffin, and sodium
picosulfate for a period of 8 weeks. Effectiveness was assessed using the Patient Assessment of Constipation Symptoms
(PAC-SYM) and Quality of Life (PAC-QoL) questionnaires, alongside weekly spontaneous bowel movements (SBMs).
Safety evaluations included adverse event (AE) monitoring, tolerability assessment and serum magnesium measurements.
Results: PAC-SYM scores decreased significantly at Week 8 (2.45±0.78 to 0.32±0.14; p<0.0001), and weekly SBMs increased
(5.82±4.31 to 14.66±3.55; p<0.0001). PAC-QoL scores improved significantly (68.86±15.90 to 33.45±6.39; p<0.0001). Treatment
was excellent for 90% of participants. One participant (2.0%) experienced mild, treatment-unrelated diarrhea. No serious AEs
were reported. Serum magnesium levels decreased slightly from 1.97 to 1.87 mg/dL (p=0.005), but remained within clinically
acceptable limits. Conclusion: The fixed-dose triple-combination laxative significantly improved constipation symptoms,
bowel frequency, and quality of life in patients with metabolic and cardiovascular comorbidities, warranting validation in
larger randomized controlled studies. Clinical Significance: This combination offers a highly effective and safe management
strategy for chronic constipation in complex patients with T2DM, hypothyroidism, and hypertension.
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