To Study Endothelial Dysfunction by Brachial Artery Flow-Mediated Dilatation and Its Relationship with Microalbuminuria in Hypertensive Individuals
DOI:
https://doi.org/10.59793/4dpmmz91Keywords:
Hypertension,, microalbuminuria,, brachial artery flow-mediated dilatationAbstract
Hypertension remains a central pathophysiologic contributor to cardiovascular morbidity and mortality.
In its earliest stage, the principal endothelial alteration is merely functional and addressed as “endothelial dysfunction”.
Flow-mediated dilatation (FMD) of the brachial artery has been widely used as a noninvasive marker to vascular reactivity.
Both microalbuminuria and endothelial dysfunction are expressions of an endothelial pathology; however, it is still uncertain
whether they are interrelated, or if the two phenomena are caused in parallel by the cardiovascular risk burden. Aim: To study
the relationship of brachial artery flow-mediated dilatation (BAFMD) with microalbuminuria in hypertensive subjects.
Method: Total 120 subjects were included in the study comprising 80 hypertension cases and 40 controls. All subjects were
subjected to anthropometric measurements and routine biochemical tests – hemogram, urea, serum creatinine, liver function
test, lipid profile, BAFMD and urinary albumin to urinary creatinine ratio (30-300 mg/g Cr). Conclusion: Mean % FMD was
lower in patients with abnormal microalbuminuria compared to normal and this was statistically verified, with p = 0.016,
thereby verifying the central hypothesis of this study.
Downloads
Published
Issue
Section
License
All open access articles published in IJCP are distributed under the terms of the CC BY-NC 4.0 license (Creative Commons Attribution-Non-Commercial 4.0 International Public License). This license permits unrestricted use, distribution, and reproduction of the articles in any medium for non-commercial purposes, provided that: The original authorship is properly and fully attributed. The IJCP is cited as the original place of publication with correct citation details. If an original work is reproduced or disseminated in part or as a derivative work, this must be clearly indicated. No articles are reproduced for commercial use without prior consent from the IJCP. All licensing requests and permissions for commercial use will be managed by the Publisher.
How to Cite
