To Study Endothelial Dysfunction by Brachial Artery Flow-Mediated Dilatation and Its Relationship with Microalbuminuria in Hypertensive Individuals

Dr SANDEEP AHARWAR; Dr ARIF MOHAMMED A

doi:10.59793/4dpmmz91

Authors

Dr SANDEEP AHARWAR Associate Professor Dept. of Medicine, Atal Bihari Vajpayee Government Medical College, Vidisha, Madhya Pradesh, India
Dr ARIF MOHAMMED A Post Graduate Student Dept. of Medicine, GR Medical College, Gwalior, Madhya Pradesh, India

DOI:

https://doi.org/10.59793/4dpmmz91

Keywords:

Hypertension,, microalbuminuria,, brachial artery flow-mediated dilatation

Abstract

Hypertension remains a central pathophysiologic contributor to cardiovascular morbidity and mortality.
In its earliest stage, the principal endothelial alteration is merely functional and addressed as “endothelial dysfunction”.
Flow-mediated dilatation (FMD) of the brachial artery has been widely used as a noninvasive marker to vascular reactivity.
Both microalbuminuria and endothelial dysfunction are expressions of an endothelial pathology; however, it is still uncertain
whether they are interrelated, or if the two phenomena are caused in parallel by the cardiovascular risk burden. Aim: To study
the relationship of brachial artery flow-mediated dilatation (BAFMD) with microalbuminuria in hypertensive subjects.
Method: Total 120 subjects were included in the study comprising 80 hypertension cases and 40 controls. All subjects were
subjected to anthropometric measurements and routine biochemical tests – hemogram, urea, serum creatinine, liver function
test, lipid profile, BAFMD and urinary albumin to urinary creatinine ratio (30-300 mg/g Cr). Conclusion: Mean % FMD was
lower in patients with abnormal microalbuminuria compared to normal and this was statistically verified, with p = 0.016,
thereby verifying the central hypothesis of this study.