Understanding Evolution of Resistant Strains in Recent Decades and Approach Towards Antibiotic Therapy
Keywords:
Antibiotics resistance, mechanisms, biofilm resistance,, multidrug resistance, extensively drug-resistanceAbstract
Developing resistance to antibiotics is a natural process, and a rising threat to human society. These emergent strains have
worsened the burden on existing regimen of antibiotic therapy. Resistance, classified under multidrug resistance (MDR),
extensively drug-resistance (XDR) and pandrug-resistance (PDR), is widely seen in hospital setup. Methicillin-resistant
Staphylococcus aureus (MRSA), vancomycin-resistant S. aureus (VRSA), Escherichia coli and Klebsiella (Resistant to thirdgeneration cephalosporins), carbapenem-resistant Enterobacteriaceae (CRE) are currently spread infectious agents which
call for careful and proper antibiotic management. Antibiotic control programs, better hygiene, antibiogram-based empirical
therapy with improved antimicrobial activity are needed to limit bacterial resistance.
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