Association between Triglyceride glucose index in type 2 diabetes mellitus patients and acute ischemic stroke

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Isha Koul
Abhinav Gupta
Ranjana Duggal
Anil Gupta
Pavan Malhotra


Background: The stroke is a leading cause of mortality and disability globally. Diabetes mellitus increases the risk of stroke. It was observed that the risk of stroke is usually higher among the young diabetic patients. It was evident that pre-diabetic patients have a great risk of stroke as the presence of glucose in blood results in vascular endothelial dysfunction, increased early-age arterial stiffness, systemic inflammation and thickening of the capillary basal membrane.In this study we aimed to determine the association between Triglyceride Glucose Index in Type-2 diabetes mellitus patients and acute ischemic stroke. 

Methods: The present prospective observational study was undertaken to elucidate the association between Triglyceride glucose index in type 2 diabetes mellitus patients and acute ischemic stroke.A total of 75 patients with acute ischemic stroke and had history of diabetes mellitus during the period of study were included in the study.

Results: In our study the mean age of the patients was 58.74±11.37 years and the majority of the patients were males (57%) followed by 43% females. The average NIHSS score of study participants was 5. The mean FPG value was as 6.13±2.03 (mmol/l), mean TC was 5.76±1.4 (mmol/l), mean TG 1.98±0.93 was (mmol/l) and mean TyG index was 8.76±0.28.

Conclusion: The present study concluded that the TyG index is an important risk factor of ischemic stroke as it was observed that the patients with higher TyG index has higher incidence of ischemic stroke.


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World Health Organization (WHO). Global status report on non-communicable diseases 2010. Geneva, World Health Organization, 2011.

Park K. Diabetes Mellitus. Park’s textbook of preventive and social Medicine 17thedn. Jabalpur: BanarasidasBhanot Publishers; 2003. Pp. 294.

Khoury JC, Kleindorfer D, Alwell K, et al. Diabetes mellitus: a risk factor for ischemic stroke in a large biracial population. Stroke. 2013; 44:1500–1504.

Chen R, Ovbiagele B, Feng W. Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes. Am J Med Sci. 2016 Apr;351(4):380-6.

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, et al. Heart disease and stroke statistics–2014 update: a report from the American heart association. Circulation (2014) 129:e28–292.

Sánchez-García A, Rodríguez-Gutiérrez R, Mancillas-Adame L, González-Nava V, Díaz González-Colmenero A, Solis RC, et al. Diagnostic accuracy of the triglyceride and glucose index for insulin resistance: A systematic review. Int J Endocrinol (2020) 2020:4678526.

Ma X, Han Y, Jiang L, Li M. Triglyceride-Glucose Index and the Prognosis of Patients with Acute Ischemic Stroke: A Meta-Analysis. HormMetab Res 2022; 54(06): 361-370.

Liu D., Yang K., Gu H. et al. Predictive effect of triglyceride-glucose index on clinical events in patients with acute ischemic stroke and type 2 diabetes mellitus. CardiovascDiabetol 21, 280 (2022).

Toh EMS, Lim AYL, Ming C, Yeo LLL, Sia CH, Tan BWQ, Leow AST, Ho JSY, Chan BPL, Sharma VK, Tan BYQ. Association of triglyceride-glucose index with clinical outcomes in patients with acute ischemic stroke receiving intravenous thrombolysis. Sci Rep. 2022 Jan 31;12(1):1596.

Zhou Y, Pan Y, Yan H, et al., Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke. Front. Neurol. 2020.

Kourtidou C, Ztriva E, Kostourou DT, et al. The Predictive Role of the Triglyceride/Glucose Index in Patients with Hypercholesterolemia and Acute Ischemic Stroke. Reviews in Crdiovascular Medicine. 2022; 23(12): 399.

GuoY, Zhao J, Zhang Y, et al. Triglyceride glucose index inuences platelet reactivity in acute ischemic stroke patients. BMC Neurol. (2021) 21:409.

Hu L, Bao H, Huang X, Zhou W, Wang T, Zhu L, Liu X, Li M, Cheng X. Relationship Between the Triglyceride Glucose Index and the Risk of First Stroke in Elderly Hypertensive Patients. Int J Gen Med. 2022;15:1271-1279.

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