Losartan: Benefits Beyond Hypertension

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Sanjay Kalra
Prabhu Kasture
Vikas Makkar


Losartan was the first angiotensin AT1 receptor blocker (ARB) approved by US Food and Drug Administration (FDA) for the treatment of hypertension. In addition to its established antihypertensive and end organ effects, several benefits of losartan beyond its antihypertensive effect have been demonstrated in clinical trials. Apart from its class effects of ARBs, losartan has pharmacokinetic and pharmacodynamic properties that are unique to it. It has shown considerable benefits as uricosuric agent, in erectile dysfunction and in prevention of stroke in hypertension patients with left ventricular hypertrophy. This review presents the benefits of losartan beyond being a hypertensive agent and associated clinical outcomes.

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Sanjay Kalra, Prabhu Kasture, & Vikas Makkar. (2022). Losartan: Benefits Beyond Hypertension. Indian Journal Of Clinical Practice, 32(12), 19–23. Retrieved from https://ojs.ijcp.in/IJCP/article/view/451
Review Article

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