Sports-Statin Interaction: Ensuring Safe and Smart Synergy

Abstract

Both sports (physical activity) and statins are recommended for the prevention and management of atherosclerotic cardiovascular
disease. The synergy that they create in risk reduction, however, may turn dysfunctional at times. Statin usage is associated with
a risk of muscle-related conditions including myalgia, myositis and rhabdomyolysis. This risk is exacerbated by unaccustomed
physical activity, exercise or sports. The communication shares practical and pragmatic suggestions regarding the prevention
and management of the potential sports-statin interactions that may occur. It also highlights the need to consider drug-lifestyle
interactions, apart from conventional drug-drug interactions.