The Obese Kidneys

Dr SOURABH SHARMA; Dr AMANDEEP SINGH; Dr NITIN KAPOOR; Dr SANJAY KALRA

doi:10.59793/txag3n45

The Obese Kidneys

Authors

Dr SOURABH SHARMA *Associate Professor, Dept. of Nephrology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
Dr AMANDEEP SINGH Assistant Professor, Dept. of Medicine, All India Institute of Medical Sciences, New Delhi, India
Dr NITIN KAPOOR Professor, Dept. of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India; Noncommunicable Disease Unit, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
Dr SANJAY KALRA Treasurer, International Society of Endocrinology (ISE); Vice President, South Asian Obesity Forum (SOF); Bharti Hospital, Karnal, Haryana, India

DOI:

https://doi.org/10.59793/txag3n45

Keywords:

Obesity,, metabolic syndrome,, CaReMe syndrome,, fatty kidney disease,, obesity-related glomerulopathy,, chronic kidney disease

Abstract

A high incidence of metabolic diseases such as type 2 diabetes mellitus and hypertension, which are well-known as a cause
of chronic kidney disease (CKD), is seen in people who are overweight or obese. This has been extensively studied and
documented when it comes to how ectopic fat affects different organs for example, the liver. Recently, obesity has also
emerged as an independent risk factor for renal disease in individuals with diabetes as well as those without diabetes.
When visceral fat accumulates in the kidneys, it causes structural alterations in the kidney along with functional damage
leading to the condition referred to as fatty kidney disease (FKD). With this review, we aim to elucidate pathophysiology,
diagnostics challenges, and available treatments for the prevention and management of FKD. This knowledge is important
for prevention and early diagnosis of CKD, guiding research and improving patient care.

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Published

2025-10-24

Issue

Vol. 36 No. 5 (2025)

Section

Review Article

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