Optimizing Finerenone Therapy: A Comprehensive Review Using the “Finerenone Pentad”

Abstract

Chronic kidney disease (CKD) is a pressing global health concern, often intertwined with comorbid conditions such as type 2
diabetes mellitus (T2DM) and cardiovascular complications. Managing CKD in T2DM patients requires a multifaceted approach,
and emerging therapeutic options are increasingly essential. Finerenone, a selective nonsteroidal mineralocorticoid receptor
antagonist, has shown considerable promise in addressing the intricate cardiorenal needs of these patients. To maximize the
effectiveness of this therapy, we propose the approach of “Finerenone Pentad” which can be utilized as a checklist while starting
and subsequently monitoring the finerenone therapy. This structured approach offers guidance on patient selection, monitoring
and outcome evaluation, ensuring a holistic approach to the care of individuals with T2DM and CKD.